Investigation on the sero-epidemiology of hepatitis B virus infection in Tibetan peasants and herdsmen of Gamba county

Abstract

Abstract: Objective To investigate the prevalence of hepatitis B surface antigen (HBsAg) among Tibetan peasants and herdsmen in high-altitude plateau of more than 4,500 meters.Methods It was retrospectively analyzed that Tibetan peasants and herdsmen received health examinations with measurements of hepatitis B virus serum markers (HBV-M) or single HBsAg, as well as patients from hospital in Gamba from 2014 to 2015. Results There were 904 peasants and herdsmen from 5 towns with the HBsAg positive rate as 20.0% (95% CI: 17.4%~22.6%), ranging from 14.1% to 30.0%. HBsAg positive rates of out-patients (n=299) and in-patients (n=299) from Gamba hospital were 24.7% (95% CI: 22.3%~32.5%) and 26.4% (95% CI: 21.4%~31.4%), respectively. There were 181 patients receiving HBV-M detection with 58.6% (95% CI: 51.4%~65.8%) showing negative results. Conclusion Tibetan peasants and herdsmen showed high HBsAg positive rate and low protection rate of HBV vaccine in Gamba, which suggests that more attention should be payed to HBV infection.

Key words: Hepatitis B virus, Hepatitis B surface antigen, Extreme altitude, Tibetan peasants and herdsmen

BAI Sang, ZHANG Hui, ZHAXI Weise, SUOLANG Ciren, LONG Hai, YE Tao, DAN Zeng, MA Shi-wu.. Investigation on the sero-epidemiology of hepatitis B virus infection in Tibetan peasants and herdsmen of Gamba county[J]. Chinese Hepatolgy, 2017, 22(4): 314-316.

References 9

[1]	羊红燕,颜中,曾德萍,等.拉萨市区2004～2006年藏族儿童入托体检乙肝血清标志物的结果分析. 中国妇幼保健,2010,25:1363-1364.
[2]	玉珍, 巴桑次仁, 罗布占堆,等.西藏高校学生乙型肝炎表面抗原携带情况调查与分析. 西藏大学学报(自然科学版), 2011,26:51-53.
[3]	王德, 赵百莉, 彭琳.西藏墨脱县1262名中小学生乙肝标志物检测结果分析. 热带医学杂志,2010,10:310-312.
[4]	李松, 吴金宝, 贺存生,等.西藏地区1063名少年儿童乙肝病毒感染状况的调查. 预防医学情报杂志,1990,6:224-226.
[5]	Liang XF,Bi SL, Yang WZ, et al. Epidemiological serosurvey of Hepatitis B in China-decliningHBV prevalence due to hepatitis B vaccination. Vaccine, 2009,27:6550-6557.
[6]	Liang XF, Bi SL, Yang WZ, et al. Evaluation of the impact of Hepatitis B vaccination amongchildren born during 1992-2005 in China. J Infect Dis, 2009,200:39-47.
[7]	中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版). 肝脏, 2015,31: 915-932.
[8]	侯枫林,汪为刚,翟银生,等. 中山某医院2009-2014年住院孕妇人群乙型肝炎血清流行病学动态研究. 中国病毒病杂志,2015,5:258-263.
[9]	李凌云.用ELISA法与胶体金法检测服务业人群HBsAg的结果比较.长治医学院学报,2004,18:92-93.

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