Chinese Hepatolgy ›› 2017, Vol. 22 ›› Issue (5): 414-417.

• Original Articles • Previous Articles     Next Articles

Role of DKK3 in non-alcoholic fatty liver disease of mice model

XIE Lan-feng1,2, SHEN Ting-ting2, ZHENG Ce2, WANG Pi-xiao3, WEI Qiao-fang3, YANG Chang-qing1, ZHANG Qin2   

  1. 1. Division of Gastroenterology and Hepatology,Tongji Hospital,Tongji University School of Medicine,Shanghai;
    2. Department of Infectious Diseases, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
    3. Cardiovascular Research Institute, Wuhan University, Wuhan, China
  • Online:2017-05-30 Published:2017-05-30
  • Contact: ZHANG Qin, Email: Zhangq1030@163.com

Abstract: Objective To investigate the role of Dickkopf-3 (DKK3) in mice with non-alcoholic fatty liver disease (NAFLD).Methods Male C57BL/6 mice were applied to establish NAFLD model with high fat diet (HFD), which was validated using detections of hepatic function, glucose metabolism, lipid content and liver pathology. DKK3 expression in liver were measured using western blot.Results In HFD group, NAFLD-related parameters were significantly elevated, while hepatic DKK product was significantly decreased compared with that in control group.Conclusion Decreased expression of hepatic DKK3 in NAFLD mice model suggests that DKK3 might play a role in the development of NAFLD.

Key words: NAFLD, Mice model, DKK3