Abstract: ObjectiveTo synthetically evaluate the risk factors of liver injury in diabetes patients in China. Methods English database (PubMed, EBSCO, Highwire, Web of Science)and Chinese database (CNKI, Wanfang, VIP )were applied for risky factor analysis in liver injury occurred in diabetes mellitus (DM) patients from 1990 to 2016. Meanwhile, relevant studies were manually retrieved. According to the inclusion and exclusion criteria, the data were screened and extracted with quality evaluation among those studies. A Meta-analysis was performed by using Revman 5.3 and Stata 12.0 software. Results Eight studies were synthetically and quantitatively analyzed, of which containing 7 Chinese studies and 1 English study. All 3568 cases in this study were divided into patients group (789 cases) and control group (2779 cases). The results of Meta-analysis showed that blood sugar level, total cholesterol (TC), triglyceride (TG), age, as well as complications of diabetes (diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic ketosis) were associated with the incidence of liver injury in DM patients. The pooled OR/SMD values were 1.52 (95%CI: 1.40~1.64), 1.31 (95%CI: 1.18~1.44), 0.78 (95%CI: 0.17~1.39), 1.42 (95%CI: 0.43~2.41), -0.1 (95%CI: -0.37~-0.1), 3.02 (95%CI: 2.32~3.93), 2.24 (95%CI: 1.66~3.02), 1.95 (95%CI: 1.39~2.31) and 2.44 (95%CI: 1.50~3.96), respectively. Conclusion Blood sugar level, TC, TG, age, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic ketosis were considered to be the risk factors for liver injury complicated with DM.

Key words: Diabetes, Liver injury, Hepatic damage, Risk factors, Meta-analysis