Abstract: Objective To analyze risk factors for hepatocellular carcinoma (HCC) among patients with chronic hepatitis B (CHB) in the era of continuous treatment with nucleos(t)ide analogues. OMethods In this study, questionnaire survey was used to collect the clinical data of 285 patients with CHB enrolled in Department of Infectious Diseases in 413 Military Hospital from March 2013 to September 2017. Risk factors for HCC were identified by univariate and multivariate analysis. Results Univariate analysis showed that gender, age, antiviral treatment, cirrhosis statue, serum hepatitis B virus (HBV) DNA level, and HCC family history were correlated with development of HCC among patients with CHB (P<0.05). Furthermore, multivariate logistic regression analysis showed that age older than 40 years (OR=3.318, P=0.019), no antiviral therapy (OR=2.709,P=0.002), HCC family history (OR=2.096,P=0.037), and cirrhosis were the main risk factors for HCC development. Child-Pugh C, B and A patients with cirrhosis all had significantly higher risk of HCC than those without cirrhosis (OR-C=18.453,OR-B=13.395,OR-A=6.970,P=0.000).Conclusion Age older than 40 years, cirrhosis statue, no antiviral treatment, family history of HCC are major risk factors for HCC development. Patients with risk factors should receive prompt antiviral treatment and be closely followed up.

Key words: Chronic Hepatitis B; Hepatocellular carcinoma; Nucleos(t)ide analogues; Risk factors