Abstract: Objective To investigate clinical characteristics of liver cirrhosis patients with portal vein thrombosis (PVT) and the related risk factors.Methods Clinical data of 218 patients with liver cirrhosis from June 2013 to June 2017 in our hospital were retrospectively analyzed, including 109 cases with PVT and 109 cases without PVT. General information, clinical manifestations, complications, laboratory examinations and imaging data were analyzed. Measurement data were compared by t-test and enumeration data were by chi-square test. Unconditional logistic regression model was applied for analyzing independent risk factors of PVT in liver cirrhosis patients.Results There were no differences in age, gender, nation, smoking, etiology, white blood cell count, platelet count, prothrombin time, international normalized ratio, activated partial prothrombin, fibrinogen, creatinine, cystatin C, total bilirubin, direct bilirubin, alanine aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase, length of spleen and width of splenic vein between PVT group and non-PVT group. However, Child-Pugh score (χ²=20.293, P=0.0001), splenectomy (χ²=11.869, P=0.001), the width of portal vein (t=3.125, P=0.002), width of spleen (t=2.283, P=0.024), hemoglobin (t=-3.751, P=0.000), albumin (t=-3.924, P=0.000), D-dimer (t=5.861, P=0.000) and fibrin degradation products (t=3.110, P=0.002) were significantly different between PVT group and non-PVT group. Occurrence of diarrhea, hepatic encephalopathy and hepatorenal syndrome showed no significant difference between two groups (P>0.05), but abdominal pain (χ²=4.598, P=0.032), fever (χ²=7.72, P=0.005), upper gastrointestinal bleeding (χ²=18.435, P=0.0001) and spontaneous peritonitis (χ²=16.987, P=0.000) were significantly different between two groups (P<0.05).Conclusion D-dimer, width of portal vein, Child-Pugh score and splenectomy are independent risk factors for PVT in liver cirrhosis patients (OR=0.686, 0.161, 3.193 and 9.515; P=0.0001, 0.007, 0.021 and 0.007, respectively). PVT in liver cirrhosis patients would aggravate clinical symptoms and increase incidence of complications.

Key words: Liver cirrhosis, Portal vein thrombosis, Risk factors, Clinical characteristics