Clinical study of the effect of liver stiffness on treatment efficacy of radiofrequency ablation in hepatocellular carcinoma patients

Abstract

Abstract: Objective To analyze the effect of liver stiffness on treatment efficacy of radiofrequency ablation in hepatocellular carcinoma (HCC) patients.Methods From October 2014 to February 2017, there were 106 patients with 114 nodules receiving ultrasound-guided radiofrequency ablation in our hospital. Liver stiffness measurement (LSM) value was measured by FibroScan before treatment and patients were divided into high-LSM group and low-LSM group with a cutoff value of 17.6 kPa. Differences of complete necrosis rate, local tumor progression rate and intrahepatic recurrence rate between the two groups were analyzed. Results The complete necrosis rates of high-LSM group and low-LSM group were 94.4% and 95.3%, respectively, which showed no statistical difference (P=0.88). The local tumor progression rates and intrahepatic recurrence rates were significantly lower in high-LSM group than those in low-LSM group (16.9% vs. 28.4%, P=0.03 and 7.0% vs. 10.3%, P=0.02, respectively). Conclusion LSM value could be a useful predictor for local tumor progression and intrahepatic recurrence after radiofrequency ablation in HCC patients.

Key words: Radiofrequency ablation, Hepatocellular carcinoma, Ultrasound, Transient elastography

LI Meng, GAO Yue-juan, LI Zhi-yan, CHEN Min, TIAN Jiang-ke, TANG Yu, ZHOU Yan-xian. Clinical study of the effect of liver stiffness on treatment efficacy of radiofrequency ablation in hepatocellular carcinoma patients[J]. Chinese Hepatolgy, 2018, 23(6): 478-480.

References

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