Chinese Hepatolgy ›› 2018, Vol. 23 ›› Issue (7): 576-579.

• Original Articles • Previous Articles     Next Articles

Baseline platelet as an independent predictor for clinical outcome after antiviral therapy in compensated HBV-related cirrhosis patients

WU Xiao-ning, ZHANG Wei, ZHOU Jia-ling, WANG Lin, SUN Ya-meng, MENG Tong-tong, GUAN Qiu-shuang, WANG Bing-qiong, CHEN Shu-yan, SHI Yi-wen, WANG Xiao-ming, YOU Hong, OU Xiao-juan, JIA Ji-dong   

  1. Liver Research Center,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center for Digestive Diseases,Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing 100050,China
  • Received:2018-05-29 Published:2020-04-28

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Abstract: Objective To investigate baseline indicators which could be predictors for liver-related events (LRE) after antiviral therapy in compensated hepatitis B virus (HBV) -related cirrhosis patients. Methods A prospective cohort of compensated HBV-related liver cirrhosis patients were followed up for observation of LRE. According to whether LRE occurred or not, patients were divided into LRE group and non-LRE group. Results A total of 106 patients with compensated HBV-related cirrhosis were recruited and followed up for 3 years. There were 18 patients (17.0%) developing LRE after 3-year follow-up, whose baseline platelet counts were lower than those in patients without LRE (P<0.05). The Cox proportional hazards model showed that baseline platelet was an independent predictor for LRE. Furthermore, the platelet counts increased more dramatically in patients without LRE than those in patients with LRE after antiviral treatment (P<0.05). HBV DNA decreased significantly in both groups after treatment, without significant difference between 2 groups. Conclusion Baseline platelet is an independent predictor for LRE in patients with compensated HBV-related cirrhosis who received antiviral therapy.

Key words: Platelet, HBV-related cirrhosis, Liver-related events, Predictor