Abstract: Objective To analyze the spectrum and trend of liver disease in our hospital, and to provide the evidence for chronic liver disease management.Methods The clinical data of inpatients with liver biopsy in our hospital from January 2007 to December 2016 were retrospectively analyzed. Results A total of 21382 patients with liver biopsy were enrolled and analyzed. In these cases, the top 5 etiologies were chronic hepatitis B (CHB), drug induced liver injury (DILI), chronic hepatitis C (CHC), cryptogenic liver disease (CLD), and autoimmune liver diseases (AILD). CHB mainly occurred in the young patients (62%). The majority of DILI was the young and middle-aged (47.7%, 36.4%). The proportions of the juvenile, young and middle-aged in CHC were similar (27.3%, 36.9%, 28.7%, respectively). The majority of CID was the juvenile and young (45.4%, 36.1%). AILD mainly occurred in the young and middle-aged (33.1%, 50.9%). In the past decade, the proportion of CHB in chronic liver disease decreased from 58.6% to 32.9%, while the proportion of DILI, CLD and AILD increased from 7.4% to 21.4%, 4.7% to 32.9% and 4.7% to 7.7%, respectively. The proportion of CHC increased from 7% to 22.4%, and then decreased to 2.2%. Moreover, the distributions differed in different gender and age groups. CHB mainly occurred in males, regardless of ages. However, DILI and AILD were more common in females, especially in middle age group. The constituent ratios of male and female in patients with CHC were similar. CLD mainly occurred in males and was more likely to occur in adolescents.Conclusion CHB and CHC are still the main causes of liver disease. However, the proportions of DILI, AILD and CID have increased rapidly, while the proportions of CHB and CHC have decreased significantly. Especially, the direct-acting antiviral therapy has achieved a great success in CHC.

Key words: Spectrum of disease, Chronic liver disease, Liver biopsy