Abstract: Objective To investigate application value of transient elastography (TE) in diagnosis of non-cirrhotic portal hypertension (PHT).Methods A total of 86 patients diagnosed with PHT in our hospital from October 2016 to October 2018 who underwent TE were enrolled. They were divided into non-cirrhotic PHT group (51 cases) and cirrhotic PHT group (35 cases) according to biopsy results. The liver stiffness value, spleen stiffness value, liver function indexes and coagulation function indexes were compared between the 2 groups. The diagnostic values of liver stiffness value and spleen stiffness value in non-cirrhotic PHT were evaluated by receiver operating characteristic (ROC) curves. Results The liver stiffness value of non-cirrhotic PHT group was lower than that of cirrhotic PHT group [(6.21 ± 5.27) vs (24.15 ± 15.79) kPa, P<0.05]. The spleen stiffness value of non-cirrhotic PHT group was higher than that of cirrhotic PHT group [(59.56 ± 17.22) vs (40.49 ± 13.78) kPa, P<0.05]. The levels of total bilirubin, aspartate aminotransferase and alanine aminotransferase in non-cirrhotic PHT group were lower than those in cirrhotic PHT group [(16.26 ± 4.28) vs (24.94 ± 5.24) μmol/L, (38.64 ± 5.69) vs (59.64 ± 9.33) U/L, (40.23 ± 5.74) vs (60.32 ± 8.14) U/L, P<0.05]. However, there was no significant difference in platelet or prothrombin time between the 2 groups (P>0.05). Besides, the area under ROC curve (AUC) and 95% confidence interval (CI) of liver stiffness value to diagnose non-cirrhotic PHT were 0.934 and 0.871-0.998, respectively, with the cutoff value of 14.05 kPa. The AUC and 95% CI of spleen stiffness value were 0.824 and 0.736-0.913, respectively, with the cutoff value of 52.8 kPa.Conclusion TE is simple and non-invasive with high accuracy to diagnose non-cirrhotic PHT. When the liver stiffness value is 14.05 kPa and spleen stiffness value is 52.84 kPa, Youden index for diagnosis of non-cirrhotic PHT is the maximum.

Key words: Portal hypertension, Non-cirrhotic, Transient elastography, Diagnosis