Abstract: Objective To investigate the medication, clinical characteristics and prognosis of 100 patients with drug-induced liver failure (DILF).Methods A retrospective review of 100 patients with DILF from April 2016 to March 2018 in our hospital were performed by analyzing the drugs leading to DILF, underlying diseases, symptoms, laboratory examination results, complications and prognosis. Results In the DILF patients, the age ranged from 8 months to 84 years, the average age was 47.51±16.71 years. And there were more female patients than male. The onset time of DILI varied greatly, with an average incubation period of 82.21 days. The top 3 kinds of drugs leading to DILF were decoction of traditional Chinese medicine, antipyretic analgesics, and Chinese patent medicine. Drugs for infectious diseases (except tuberculosis), dermatosis and tuberculosis were the top 3 in patients with underlying diseases. DILF was mainly subacute (57, 57.0%) according to the duration, and was mainly hepatocyte injury (63, 63.0%) according to clinical classification. The prognosis of acute DILF was worse than that of subacute DILF (P=0.023). In the 100 patients, 11 (11.0%) were cured, 37 (37.0%) were improved, 44 (44.0%) experienced treatment failure and 8 (8.0%) were dead. The levels of aspartate aminotransferase, total bilirubin, gamma-glutamyltransferase, international normalized ratio, blood ammonia in cured or improved patients were apparently lower than those in patients experienced treatment failure or dead from DILF (P<0.05), while the levels of albumin, plasma prothrombin activity, total bile acid, total cholesterol, platelet were higher (P<0.05). The top 3 complications were hydrothorax/ascites, hyponatremia and infection. Among the complications, hyponatremia, infection, hepatic encephalopathy, hepatorenal syndrome, shock and hemorrhage were associated with poor prognosis (P<0.05).Conclusion DILF is characterized by acute onset, more and serious complications, therefore, clinicians need to strengthen drug control and monitor the adverse reactions during the course of treatment.

Key words: Drug-induced liver injury, Liver failure, Clinical feature, Prognosis