Abstract: Objective To study the perinatal outcomes of early- and late-onset intrahepatic cholestasis of pregnancy.Methods A total of 170 patients with intrahepatic cholestasis of pregnancy admitted to our hospital from December 2016 to December 2018 were divided into observation group (early-onset type, < 28 gestational weeks, 68 cases) and control group (late-onset type, ≥ 28 gestational weeks, 102 cases). The occurrences of mild and severe intrahepatic cholestasis of pregnancy in 2 groups were counted. The biochemical indexes including serum total bile acid, glycocholic acid, alanine aminotransferase, aspartate transaminase, alkaline phosphatase, total cholesterol, triglycerides, fasting blood glucose, glycosylated hemoglobin were tested. Labor gestational age, birth weight, Apgar score, postpartum blood loss and perinatal outcome were recorded. Results In the observation group, the incidence of severe intrahepatic cholestasis of pregnancy and the serum total bile acid, glycocholic acid, total cholesterol, triglyceride and fasting blood sugar were significantly higher than that in the control group (P<0.05), inversely, the alanine aminotransferase, aspartate transferase and alkaline phosphatase were significantly lower than those in the control group (P<0.05). In the observation group, the gestational weeks of delivery were significantly shorter than those in the control group (P<0.05), the neonatal weight was significantly lower than that in the control group (P<0.05), and the Apgar score was significantly higher than that in the control group (P<0.05). Moreover, the incidences of cesarean section, neonatal asphyxia, grade II to III amniotic fluid pollution and premature delivery in the observation group were significantly higher than those in the control group (P<0.05).Conclusion Compared with late-onset intrahepatic cholestasis of pregnancy patients, early-onset patients have worse perinatal outcomes. Therefore, they should be paid more attention to clinically.

Key words: Intrahepatic cholestasis of pregnancy, Early onset, Late onset, Perinatal outcome