Evaluation of diffusion kurtosis imaging in diagnosing peritumoral infiltration in patients with hepatocellular carcinoma

Abstract

Abstract: Objective To evaluate the value of diffusion kurtosis imaging (DKI) in diagnosing the peritumoral infiltration of hepatocellular carcinoma. Methods Fifty-six cases of liver cancer patients admitted to our hospital from October 2017 to October 2019 were included as the liver cancer group, and 56 cases of healthy physical examination persons admitted during the same period were selected as control group. All of the them received DKI scanning. Liver cancer tissue, peritumoral liver parenchyma and distant liver parenchyma were examined in the liver cancer group, respectively, as group A, B and C. DKI parameters of the 4 groups were recorded. According to the clinical comprehensive diagnosis, patients with liver cancer were divided into peritumoral infiltration group (41 cases) and non-peritumoral infiltration group (15 cases). The value of DKI parameters in diagnosing the peritumoral infiltration of liver cancer was analyzed. Results The mean diffusivity (MD), radial diffusivity (Dr) and axial diffusivity (Da) of group A, B and C were significantly lower than those of control group, and fractional anisotropy (FA), axial kurtosis (Ka) and fractional anisotropy of kurtosis (FAk) were significantly higher than those of control group (P<0.05). The MD, Dr and Da of group A were significantly lower than those of group B and group C, and the FA of group A was significantly lower than that of group B (P<0.05). MD, Dr And Da in peritumoral infiltration group were significantly lower than those in non-peritumoral infiltration group, and Ka was significantly higher than that in non-peritumoral infiltration group (P<0.05). The area under the receiver operating characteristic curve of MD, Dr, Da and Ka were 0.749, 0.733, 0.720 and 0.685, respectively. Conclusion DKI has high value in diagnosing the peritumoral infiltration of liver cancer. MD, Dr, Da and Ka can be used as the focused parameters to diagnose peritumoral infiltration in liver cancer patients.

Key words: Liver cancer, Liver parenchyma, Infiltration around cancer cells, Diffusion kurtosis imaging

ZHAO Hai-yang, TANG De, JIANG Kai. Evaluation of diffusion kurtosis imaging in diagnosing peritumoral infiltration in patients with hepatocellular carcinoma[J]. Chinese Hepatolgy, 2020, 25(10): 1065-1067.

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