Abstract: Objective To analyze the value of conventional ultrasound combined with LAMP2,ARFI in monitoring the degree of hepatic fibrosis in patients with PBC. Methods The complete data of 96 patients with PBC diagnosed by liver puncture and pathology from February 2016 to April 2019 were analyzed retrospectively. in addition, 60 patients who underwent physical examination in our hospital were randomly selected as the control group. All the subjects were examined by routine ultrasound, the expression of LAMP2 was detected by immunohistochemistry, and the ARFI. of each group was detected also. Results The scores of ARFI,LAMP2 and ultrasound images in PBC patients were significantly higher than those in control group (P < 0.05). The results of F test showed that there were significant differences in ARFI,LAMP2 and ultrasound scores among PBC patients with different Child-Pugh grades. T test showed that ARFI,LAMP2 and ultrasound scores in patients with grade B Child-Pugh were significantly higher than those in patients with grade A. ARFI,LAMP2 and ultrasound scores in patients with Child-Pugh grade C were significantly higher than those in patients with grade A and B (P < 0.05). LAMP2, ARFI and ultrasound scores were positively correlated with Child-Pugh grade in patients with PBC (P<0.05). Conclusion Conventional ultrasound combined with LAMP2,ARFI can accurately evaluate the degree of hepatic fibrosis in patients with PBC, and has high diagnostic value.

Key words: conventional ultrasound, LAMP2, ARFI, PBC, liver fibrosis