Abstract: Objective To evaluate the adherence of patients with chronic hepatitis B (CHB) to nucleos(t)ide analogues (NAs) and relative affecting factors.Methods This study is a cross-sectional study which collected clinical data of CHB patients taking NAs and investigated their compliance.Logistic regression analysis was used to evaluate the effect of different factors on medication adherence.Results 113 CHB patients were enrolled in this study.35 (31.0%) patients reported that they missed more than one dose in the past three months.Multivariate logistic regression analysis showed that patients younger than 30 years old (P=0.034),self-paid drugs (P=0.031),combined with 2 or more chronic diseases (P=0.021),and patients who did not insist on regular follow-up in the same clinic is more likely to have poor adherence (P=0.012).For patients with poor adherence,the one-year HBV DNA conversion rate was significantly lower than patients with good adherence (51.4% vs.79.4%,P=0.004),and the incidence of virological breakthrough was significantly higher than that with good adherence (14.3% vs.2.6%,P=0.017).Conclusion Our study found that certain factors such as age less than 30 years old,self-financed drugs,combined with other chronic diseases,and failure to adhere to regular follow-up in the same clinic were associated with poor medication adherence in CHB patients.We also confirmed that the poor adherence is directly related to the antiviral therapy effect of HBV infection.These findings can help medical staff to intervene and guide patients to improve the overall adherence of antiviral therapy,and ultimately improve the therapeutic effect.

Key words: Chronic hepatitis B, Nucleos(t)ide analogue, Antiviral therapy, Adherence, Affecting factor