Abstract: Objective To explore the changes of liver function of pregnant women with chronic hepatitis B virus (HBV) infection after discontinuing antiviral treatment during delivery.Methods A retrospective study was carried out in 110 pregnant women with chronic HBV infection.They were divided into antiviral group (n=55) and control group (n=55).Patients in the antiviral group had received antiviral treatment,whereas patients in the control group remained untreated.The changes of blood routine test,including white blood cell count (WBC),platelet (PLT) and neutrophil,and the levels of HBV DNA,Creatinine (Cr),Total bilirubin (TBil),Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were measured before antiviral treatment,prenatal and 8 weeks after delivery.The changes of liver function were analyzed.Results The cesarean section rate,postpartum hemorrhage rate and adverse pregnancy rate of the antiviral group were 60.00%,25.45% and 9.09%,respectively.There was no difference compared with 56.36%,21.82% and 10.91% of the control group (P>0.05).The HBV DNA quantity,Cr,TBil,ALT,AST in the antiviral group were lower than those in the control group before and 8 weeks after delivery (P<0.05).Conclusion The discontinuing of antiviral drugs during delivery in pregnant women with chronic HBV infection was not associated with abnormal liver function in 8 weeks after delivery,indicating that it was safe to temperately discontinue antiviral treatment during dilivery.

Key words: Chronic hepatitis B, Pregnant woman, Antiviral therapy, Liver function