Significance of serum high molecular weight adiponectin in patients with non-alcoholic fatty liver disease

Abstract

Abstract: Objective To investigate the changes and clinical significance of serum high molecular weight adiponectin (HMW-APN) in patients with nonalcoholic fatty liver disease (NAFLD).Methods From Jan 2017 to Jan 2020,106 patients with NAFLD (NAFLD group) (74 males and 32 females), aged (43.5±6.7) years old, were admitted to our hospital. A total of 100 healthy patients (control group) (66 males and 34 females) with an age of (42.5±7.8) years old were collected. T-test was used for measurement data, chi-square test was used for counting data, Pearson correlation analysis was used to explore the correlation, and Logistic regression analysis was used to explore the influencing factors of NAFLD.Results Comparing the general data of NAFLD group and control group, the BMI of NAFLD group was (26.1±2.3) kg/m², while that of control group was (23.4±2.3) kg/m², with significant difference between the two groups (P<0.05). The HMW-APN in NAFLD group was (1.8±2.1) μg/mL, while that in control group was (3.2±2.6) μg/mL, with significant difference between the two groups (P<0.05). The TG of NAFLD group was (1.6±0.7) mmol/L, while that of control group was (1.2±0.5) mmol/L, with significant difference between the two groups (P<0.05). TC in NAFLD group was (4.7±0.8) mmol/L, while that in control group was (4.1±0.6) mmol/L, with significant difference between the two groups (P<0.05). LDL-C in NAFLD group was (1.8±0.5) mmol/l while LDL-C in control group was (1.6±0.5) mmol/L, with significant difference between the two groups (P<0.05). HDL-C in NAFLD group was (1.4±0.3) mmol/L, while HDL-C in control group was (1.2±0.2) mmol/L, with significant difference between the two groups (P<0.05). The FBG in NAFLD group was (5.1±0.5) mmol/L, while that in control group was (4.7±0.4) mmol/L, with significant difference between the two groups (P<0.05). HbAIC in NAFLD group was (13.3±3.0)% and that in control group was (5.5±1.4)%, with significant difference between the two groups (P<0.05). However, there was no significant difference in waist-hip ratio, AST and ALT between the two groups (P>0.05). Pearson correlation analysis showed that serum HMW-APN level was significantly negatively correlated with TG (r=-0.402), TC (r=-0.176), LDL-C (r=-0.148), FBG (r=-0.374) and HbAIC (r=-0.485) (P<0.05), while was significantly positively correlated with HDL-C (r=0.316) (P<0.05). Taking the occurrence of NAFLD as dependent variable (yes = 1, no = 0), multivariate Logistic regression analysis showed that HMW-APN was a protective factor for NAFLD, while BMI, TG, TC, FPG and HbAIC were independent risk factors.Conclusion Serum HMW-APN is significantly reduced in NAFLD patients. High level serum HMW-APN is a protective factor for NAFLD, while low level serum HMW-APN may predict NAFLD occurrence.

Key words: Nonalcoholic fatty liver disease, High molecular weight adiponectin, Pearson correlation analysis, Logistic regression analysis

XU Jian-hao, JU Feng, ZHANG Yan. Significance of serum high molecular weight adiponectin in patients with non-alcoholic fatty liver disease[J]. Chinese Hepatolgy, 2020, 25(12): 1313-1316.

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