Chinese Hepatolgy ›› 2020, Vol. 25 ›› Issue (2): 131-134.

• Viral Hepatitis • Previous Articles     Next Articles

Differential expression of T lymphocyte and NK G2D in patients with chronic HBV infection in different immune states

WANG Xian, LIN Tao-fa, ZHAN Zhi-yu, WANG Shao-yang   

  1. Department of Infectious Diseases, The 900th Hospital of Joint Logistic Support Force PLA. Fuzhou, Fujian 350003,China
  • Received:2019-07-16 Online:2020-02-29 Published:2020-03-26
  • Contact: WANG Shao-yang, Email: wsyang2005@163.com

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Abstract: Objective To investigate the difference of T lymphocyte and natural killer cell G2D (NKG2D) expression in chronic HBV infected persons under different immune conditions. Methods Eighty patients with chronic HBV infection were divided into immune tolerance group (28 cases), immune clearance group (30 cases) and low (non) replication group (22 cases) according to the different immune status. Another 30 healthy people were selected as control group. Peripheral blood T lymphocyte subsets, NK cells, NKG2D cell frequencies and serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-γ were measured among four groups. Results The percentage of CD3+ T cells in the four groups was not statistically significant (P>0.05). The percentage of CD4+, CD4+/CD8+, NK cells in the immune clearance group were (30.14±5.36) %, (1.10±0.33)%, (9.67±4.31)%, which were significantly lower than the other three groups. The percentage of CD8+, NKG2D+/NK cells were (33.56±5.37)%, (12.96±3.42)%, which were significantly higher than the other three groups (P<0.05). The percentage of NKG2D+/NK cells in immune tolerance group and low (non) replication group were (3.46±1.15)% and (3.55±1.07)% respectively, which were significantly lower than that in control group, and the percentage of NKG2D+/NK cells in immune clearance group was significantly higher than that in control group (P<0.05). The levels of TNF-α and IFN-γ in immune clearance group were (69.62±16.46) ng/L and (69.85±12.30) ng/L respectively, which were significantly higher than those in immune tolerance group, low (non) replication group and control group (P<0.05). There was no significant difference in the levels of TNF-α and IFN-γ between the immune tolerance group, the low (non) replication group and the control group (P>0.05). Conclusion The expression of peripheral blood lymphocyte and NKG2D cells in patients with chronic HBV infection is significantly different under different immune conditions. The immune status of patients can be evaluated by measuring the levels of peripheral blood T lymphocyte and NKG2D cells in patients with HBV infection to guide clinical treatment.

Key words: hepatitis B virus, immune status, natural killer cells, lymphocyte subsets