Abstract: Objective To compare the clinical effects of percutaneous radiofrequency ablation and laparoscopic liver resection for primary stage Ia hepatocellular carcinoma. Methods A total of 114 patients with stage Ia primary liver cancer admitted to Luotian County People's Hospital from January 2015 to January 2017 were enrolled. The patients were randomly divided into PRFA group and laparoscopic group, with 57 cases in each group. The PRFA group underwent percutaneous radiofrequency ablation, and the laparoscopic group underwent laparoscopic liver resection. The survival time and tumor-free survival time of the two groups were compared. The liver function of the two groups was compared before and after treatment. The complication rate of the two groups was compared. Results After treatment, the total incidence of complications in the PRFA group was 7.02% (4/57), and the total incidence of complications in the laparoscopic group was 24.56% (14/57). The total incidence of complications in the PRFA group. The difference was statistically significant (P<0.05). There was no significant difference in serum ALT and AST levels between the two groups before treatment (P>0.05). After 1 month of treatment, the two groups were treated. The liver function level of patients was significantly better than that before treatment, and the liver function level of patients in PRFA group was significantly better than that of laparoscopic group, the difference was statistically significant (P<0.05). After treatment, the survival time and tumor-free survival time of the patients in the laparoscopic group were (28.30±4.11) months and (22.67±3.99) months, respectively, and the survival time and absence of the patients in the PRFA group were (34.29±2.88) months and (27.14±4.16) months, respectively. The tumor survival time was significantly better than that of the endoscopy group, and the difference was statistically significant (P<0.05). Conclusion For the treatment of stage Ia primary liver cancer, percutaneous radiofrequency ablation is more conducive to liver function recovery than laparoscopic liver resection, which can effectively prolong the survival time and tumor-free survival time, and reduce the incidence of complications is worthy of clinical promotion.

Key words: Percutaneous radiofrequency ablation, Laparoscopic liver resection, Stage Ia primary liver cancer, Survival time, Liver function, Safety