Abstract: Objective To investigate the clinical characteristics of systemic lupus erythematosus with non primary biliary cirrhosis.Methods Retrospectively assessed 11 cases diagnosed as systemic lupus erythematosus with non primary biliary cirrhosis between January 2013 and January 2019 at the Second Affiliated Hospital of Fujian Medical University. Results They were all female with median age of 57-year-old and their condition were all severe;7 cases were first diagnosed as SLE because of discovery of cirrhosis,with 3 of them passing away 1 day after living hospital and 1 passing away after 1 year.2 patients with hepatic encephalopathy,renal insufficiency,high bilirubin,largely elevated CA125 and CA199 had a rapid deterioration of illness and died in a short time.Only 3 cases of them were stable,1 case with a history of SLE before having regular treatment of SLE and 1 case diagnosed as hepatitis B infection accepting regular antiviral treatment.Conclusion Female were more seen in SLE with non biliary cirrhosis and the condition were usually severe.These patients had a bad prognosis as a whole. A large majority of people were first diagnosed as SLE because of cirrhosis,and often they had worse prognosis.Hepatic encephalopathy,renal insufficiency,high bilirubin,largely elevated CA125 and CA199 may suggest a bad result.Accepting regular treatment of SLE with a SLE history and antiviral treatment with a definite hepatitis B virus infection may improve the prognosis.

Key words: Systemic erythematosus, Cirrhosis, Nnon primary biliary cirrhosis, Hepatitis B virus, Liver cancer