Abstract: Objective To study the risk factors of chronic graft-versus-host disease (cGVHD) in liver after hematopoietic stem cell transplantation (HSCT).Methods 149 patients with HSCT admitted to our hospital from April 2014 to April 2019 were enrolled in this study and retrospectively analyzed.General data of the patients were collected and postoperative liver cGVHD incidence was analyzed. Multivariate Logistic regression analysis was used to analyze the independent influencing factors of postoperative liver cGVHD complicated with HSCT. Results Among 149 patients with HSCT, 40 patients had postoperative liver cGVHD, accounting for 26.85%; Liver cGVHD did not occur in 109 patients, accounting for 73.15%.Multivariate logistic regression analysis showed that the use of ATG (OR=0.235, 95%CI=0.113～0.490) and early onset of aGVHD (OR=2.089, 95%CI=1.020～4.279) were independent influencing factors of liver cGVHD after HSCT (P<0.05).Conclusion The occurrence of hepatic cGVHD after HSCT is related to the occurrence of cGVHD in the early stage of transplantation, and the use of ATG in the early prevention of GVHD can reduce the incidence.

Key words: Hematopoietic stem cell transplantation, Liver, Chronicity graft-versus-host disease, Risk Factors