Abstract: Objective To investigate the value of chronic liver failure sequential organ failure assessment (CLIF-SOFA) score in predicting organ failure in patients with hepatitis B virus associated acute-on-chronic liver failure (HBV-ACLF).Methods A total of 100 HBV-ACLF patients admitted to our hospital from August 2016 to August 2019 were divided into organ failure group and non-organ failure group according to the condition of organ involvement. The CLIF-SOFA scores were compared between the 2 groups. The receiver operator characteristic (ROC) curve was used to analyze the predictive value of CLIF-SOFA scores for organ failure. On the day of admission, 2 mL of fasting venous blood was collected. The levels of total bilirubin (TBil), total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alpha fetoprotein (AFP) and leukocyte count (WBC) were measured. Correlation between CLIF-SOFA score and serum indexes were analyzed by Pearson correlation coefficient.Results Of the 100 cases, 21 (21.00%) had no organ failure and 79 (79.00%) had organ failure. The organ failure group had higher CLIF-SOFA score (6.19±1.04) than the non-organ failure group (4.17±1.01) (P<0.05). The area under the ROC curve of CLIF-SOFA score was 0.808 (standard error = 0.053, P=0.000, 95% confidence interval = 0.705-0.911). Serum TBil and WBC in organ failure group [(384.64±15.89) μmol/L, (7.94±1.56) × 10⁹/L] were significantly higher than those in non-organ failure group [(189.48±17.84) μmol/L, (6.21±1.75) × 10⁹/L] (P<0.05). TC, ALT and AST in organ failure group [(1.76±0.34) mmol/L, (384.50±96.76) U/L, (328.91±91.12) U/L] were significantly lower than those in non-organ failure group [(2.32±0.83) mmol/L , (645.41±124.64) U/L, (552.32±114.76) U/L] (P<0.05). The CLIF-SOFA score of HBV-ACLF patients with organ failure was positively correlated with serum TBil and WBC (r=0.616, 0.824, P<0.05), and negatively correlated with ALT and AST (r=-0.742, -0.574, P<0.05).Conclusion CLIF-SOFA score can predict organ failure in patients with HBV-ACLF, which is related to TBil, WBC, ALT and AST.

Key words: Chronic liver failure sequential organ failure assessment, Hepatitis B virus, Acute-on- chronic liver failure, Organ failure