Abstract: Objective To investigate an optimized method for measuring hepatic venous pressure gradient (HVPG). The consuming time and the incidence of complications between the transjugular and the modified transfemoral methods were compared. Methods Sixty patients who received HVPG measurement at Beijing Friendship Hospital, Capital Medical University between December 2017 to December 2019 were studied. They were divided into two groups (with 30 cases in each group) according to a random number table. The HVPG in one group of patients were measured with the modified transfemoral method, using 7F RDC guiding catheter in combination with 5.5F double-lumen balloon catheter. The consuming time of catheterization and the incidence of complications between the transjugular group and the modified transfemoral group were compared. Results HVPG was successfully measured in all 60 subjects. The average catheterization time (145±25)s in the modified transfemoral group was less than that in the transjugular group (227±34)s(t=10.511,P=0.000),The incidence rate of supraventricular tachycardia in the modified transfemoral group (3.33%) was lower than that in the transjugular group (36.67%)(χ²=21.600,P=0.000), The incidence rate of anxiety in the modified transfemoral group (6.67%) was lower than that in the transjugular group (23.33%)(χ²=29.400,P=0.000, all have statistical significant differences. Conclusion For measuring HVPG, the modified transfemoral method may shorten the operating time, and therefore is a safety and clinically desirable approach.

Key words: Hepatic venous pressure gradient, Transjugular method, Modified transfemoral method