Abstract: Objective To investigate the effect of non-selective beta blockers (NSBBs) on circulation and incidence of hepatorenal syndrome (HRS) in patients with cirrhosis complicated with esophageal and gastric varices. Methods 135 patients with cirrhosis complicated with esophageal and gastric varices and treated in our hospital from January 2017 to March 2019 were divided into NSBBs group (n=85) and routine group (n=50) according to different treatment schemes. The general data, laboratory parameters, hemodynamic parameters [resting heart rate (RHR), arterial systolic pressure (SAP), mean arterial pressure (MAP)], and the incidence of HRS were collected. Results After treatment, RHR was decreased in both groups, and SAP and MAP were increased in both groups, moreover, NSBBs group had lower SAP and MAP than those in routine group (P<0.05). The incidence of HRS in NSBBs group was higher than that in routine group (P<0.05). Varicose and ascites severity, SAP, MAP and NSBBs treatment were high risk factors for HRS (P<0.05). Conclusion NSBBs can damage the circulatory system of cirrhosis patients with gastric varices, and may increase the incidence of HRS during the treatment due to the increased severity degrees.

Key words: NSBBs, Liver cirrhosis with gastric varices, Circulation, HRS, Effect