Abstract: Objective To study on the application value of serum 25-hydroxyvitamin D [25(OH)D] in the evaluation of progressive liver fibrosis in patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Methods The clinical data of 265 T2DM patients with NAFLD enrolled in our hospital from May 2015 to May 2019 were retrospectively analyzed for their status of liver fibrosis progression. Multi-factor Logistic regression analysis was applied to investigate the independent factors, and to determine the predictive value of serum 25(OH)D for progressive liver fibrosis. Results Of the 265 patients, 80 (30.19%) had progressive liver fibrosis. In addition to age, the course of diabetes mellitus, body mass index, hemoglobin, albumin, alanine aminotransferase, ratio of aspartate aminotransferase and alanine aminotransferase, serum creatinine, cystatin C and 24-hour urinary microalbumin, serum 25(OH)D was also an independent predictive factor associated with liver fibrosis progression (P<0.05) with the area under curve (ROC)of 0.831. Conclusion Serum 25(OH)D plays an important role in the assessment of progressive liver fibrosis in patients with T2DM accompanied with NAFLD.

Key words: 25-hydroxyvitamin D, Type 2 diabetes mellitus, Nonalcoholic fatty liver disease, Progressive liver fibrosis