Abstract: Objective To investigate the clinical effect of ERCP combined with praziquantel in the treatment of hepatic fluke infection complicated with biliary obstruction. Methods The clinical data of 33 patients with liver fluke disease complicated with biliary obstruction admitted to our hospital from January 2016 to January 2018 were retrospectively analyzed at the same time as the clinical data of 33 patients with liver fluke infection and biliary obstruction previously admitted to our hospital. Among them, 33 cases received ERCP combined with praziquantel treatment, 33 cases received ERCP surgery, and all patients received anti-tremoria treatment after admission. Compare the data of surgical success rate and postoperative complications, length of hospital stay, hospital expenses of the two groups, compare the alanine aminotransferase(ALT), gamma-GGTP (gamma glutamyl transpeptidase) (GGT), total bilirubin (TBIL) and alkaline phosphatase (ALP) levels before and after treatment in the two groups. In addition, statistics on the occurrence of adverse reactions after ERCP surgery combined with praziquantel. Results There was no significant difference between the two groups in effective rate, length of stay and cost of stay (P>.05). Before treatment, there was no significant difference in ALT, GGT, ALP and TBil between the two groups (P>0.05). After treatment, the levels of ALT, GGT, ALP and TBil decreased in the two groups, but there was no significant difference between the two groups (P>0.05). After treatment, the levels of ALT, GGT, ALP and TBil in the two groups showed a downward trend, and the intra-group comparison difference was significantly lower than that before treatment, with statistically significant differences (P<0.05). There was no significant difference in the total incidence of postoperative complications between the two groups (P>.05). Headache, dizziness and tachycardia occurred in 1 case after ERCP combined with praziquantel, and no obvious adverse reactions were observed in ERCP group. Headache and dizziness were mild reactions, which were relieved by themselves without special treatment. Tachycardia improved after symptomatic treatment. Conclusion ERCP combined with praziquantel for the treatment of liver fluke infection complicated with biliary tract obstruction is safe and effective, which can eliminate the biliary tract obstruction and kill the liver fluke at the same time, and can improve the liver function of patients, which is worthy of clinical application.

Key words: Liver fluke infection, Biliary obstruction, ERCP operation, Liver function