Abstract: Objective To investigate the effects of intrahepatic cholestasis of pregnancy (ICP) on liver function, inflammatory cytokines and fetal outcomes. Methods Between August 2014 and August 2019, there were 96 patients with ICP (ICP group), with an average of (29.5±1.3) years old. ICP accorded with the Diagnostic criteria of ICP in Obstetrics and Gynecology (7th edition). Another 100 patients with normal pregnancy were selected in the same period (control group). There was no significant difference in age, pregnancy and cesarean section between the two groups (P>0.05). T-test comparison of measurement data and χ² test comparison of counting data. Results Serum bile acid (TBA), ALT and AST in ICP group were (35.9±5.8) μmol/l, (70.7±6.1) u/l and (86.0±7.9) u/l, which were significantly different from those in control group (4.7±1.1) μmol/l, (16.0±4.1) u/l and (14.6±4.2) u/l, respectively) (P<0.05). Hs-CRP, IL-6 and TNF-α in ICP group were (13.5±0.6)mg/L/l, (0.7±0.1) ng/l and (142.0±7.9)ng/L/l, which were significantly different from those in control group (8.4±0.4) mg/l, (0.4±0.1) ng/l and (82.6±5.2) ng/l, respectively) (P<0.05). The neonatal weight, gestational week, Apgar score at 1 minute of birth, amniotic fluid turbidity, intrauterine distress and neonatal jaundice in ICP group were (2860.4±30.5) g, (36.2±1.2) weeks, (8.2±0.3) minutes, 33 cases (34.4%), 12 cases (12.5%) and 28 cases (29.2%), Compared with the control group [3205.8±40.2)g, (38.6±1.2) weeks, (9.4±0.4) minutes, 7 cases (7.0%), 4 cases (4.0%) and 8 cases (8.0%)] there was significant difference (P<0.05). Conclusion ICP patients have abnormal liver function and higher inflammatory cytokines than normal patients. compared with normal patients, ICP patients have a higher incidence of fetal adverse outcome, which should be paid more attention to in clinic.

Key words: Intrahepatic cholestasis of pregnancy, Apgar score