Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (10): 1157-1162.

• Other Liver Diseases • Previous Articles     Next Articles

Investigation on the prevalence and risk factors of fatty liver disease in 2961 in-service medical staff

LI Xiao-he, LIU Hui-xin, CHEN Hong-song, RAO Hui-ying   

  1. Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis,Beijing 100044, China
  • Received:2021-03-11 Online:2021-10-31 Published:2021-12-07
  • Contact: RAO Hui-ying, Email:huiying@163.com, CHEN Hong-song, Email: chenhongsong@pkuph.edu.cn

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Abstract: Objective To investigate the prevalence, distribution and risk factors of fatty liver disease (FLD) of in-service medical staff. Methods A cross-sectional study was designed to collect the physical examination results of medical staff in a large general hospital in Beijing from July to August 2019. The relationship between age, gender, metabolic factors and FLD were analyzed. Univariate and multivariate logistic regression were used to analyze the influencing factors of FLD. Results Prevalence rate of FLD was 22.32 (661/2961), with 48.09% (290/603) in male and 15.73% (371/2357) in female(χ2=289.98,P<0.001). The prevalence rates of male aged 20-29, 30-39, 40-49 and ≥ 50 years old were 34.5%(35/110), 46.9%(105/224), 55.1% (70/127) and 56.3% (80/142), respectively (χ2=202.30, P<0.001), with significant higher incidence than women in each age group, 5.5% (38/632), 12.0% (110/914), 21.7% (117/538) and 38.8%(106/273), all P value＜0.001. The prevalence of moderate to severe FLD was about 5% (38/632), with male (12.11%, 73/603) more than female (3.18%, 75/2357) (χ2=80.56, P<0.001). Age, gender, overweight/ obesity, FBG ≥ 7.0 mmol/L, dyslipidemia, hypertension and hyperuricemia were all influential factors for FLD (all P<0.05). After stratification for age, overweight/obesity (OR 3.92-13.54) and hypertriglyceridemia (OR 2.91-3.67) were risk factors in all groups of age. Compared with normal level of uric acid populations, staffs with hyperuricemia were at an increased risk for FLD by 7.28 (95%CI: 3.92-13.54) fold and 2.01 (95%CI: 1.34-3.03) fold in group 20-29 and 30-39 years old,respectively. The risk increased about 4.3-and 2-fold in group of 40-49 and ≥50 years old (P<0.01) due to diabetes. Conclusion The prevalence of FLD in serving medical staffs in Beijing was increased with age, and men tend to have a higher prevalence rate than women. Overweight/obesity, hyperuricemia, abnormal glucose metabolism, hypertension and dyslipidemia were major causes of FLD.

Key words: Fatty liver disease, Serving medical staffs, Physical examination, Risk factors