Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (12): 1356-1359.

• Viral Hepatitis • Previous Articles     Next Articles

Diagnostic value of real-time shear wave elastography for different stages of hepatic fibrosis in children

TANG Wen-Jing1, ZHU Ting1, FANG Jin1, WANG Song-Ping2   

  1. 1. Department of Ultrasound, Shenzhen Union Hospital of Huazhong University of Science and Technology, Guangdong 518000, China;
    2. Department of General Surgery, Second People's Hospital of Anhui Province, Hefei 230000, China
  • Received:2021-04-03 Published:2022-01-13

Abstract: Objective To analyze the clinical value of real-time shear wave elastography (SWE) in evaluating the stages of liver fibrosis in children. Methods Eighty-five children with chronic liver diseases or biliary atresia admitted from January 2018 to December 2020 were selected. Routine serological tests and real-time shear wave elastography were performed in all children. The pathological results of liver biopsies were used as the "Gold standard" for diagnosing liver fibrosis, and in the comparison between the efficacies of serum markers and SWE indexes in evaluating the stages of liver fibrosis, as well as the diagnostic value of SWE. Results There were significant differences in serum procollagen III (PC III), collagen type IV (IV C), hyaluronic acid (HA), laminin (LN) and elastic modulus among children with fibrosis ≥ S1, ≥ S2, ≥ S3 and S4 stages, and the serum PC III, IV C, HA, LN and elastic modulus increased significantly (P<0.05). SWE elastic modulus was positively correlated with PC III, IV C, HA, LN and the stage of liver fibrosis (P<0.05). The AUC (area under the curve) of SWE elastic modulus for the diagnosis of liver fibrosis in children ≥S1, ≥S2, ≥S3 and S4 stages were 0.818, 0.821, 0.837 and 0.829, and the best cut-off values were 5.57 kPa, 7.21 kPa, 8.33 kPa and 9.62 kPa, respectively. The sensitivity was 64.77%, 63.21%, 59.87% and 65.13%, and the specificity was 94.37%, 92.32%, 90.11% and 87.48%, respectively. Conclusion SWE technique quantitatively detects liver fibrosis with good diagnostic efficacy for different stages of liver fibrosis in children, and provides a reference for the diagnosis and treatment of liver fibrosis in children with chronic liver diseases.

Key words: Real time shear wave elastography, Chronic liver diseases, Pathology, Children, Hepatic fibrosis, Diagnostic value