Abstract: Objective To investigate the prognostic factors for hepatorenal syndrome (HRS) in patients with cirrhosis.Methods Ninety-seventy HRS patients admitted to our hospital from January 2019 to December 2019 were divided into a survival group and a death group. Multivariate logistic regression was used to analyze the factors affecting the 28-day prognosis of patients. Results HRS survival rate during hospitalization was 24.74%. The alanine aminotransferase, serum total bilirubin, total bile acid, and the model of end-stage liver disease (MELD) score in the death group were 56.00 (31.60, 114.00) IU/L, 141.51 (51.20, 328.93) μmol/L, 67.21 (28.40, 133.76) μmol/L and 27.00 (20.00, 34.00), respectively, significantly different from 38.00 (21.00, 56.00) IU/L, 45.30 (20.11, 75.00) μmol / L, 27.86 (17.26, 42.10) μmol/L and 18.00 (15.50, 24.50) in the survival group (P<0.05). HRS classification, infection, MELD score and hepatic encephalopathy were related to prognosis (P<0.05). Multivariate logistic regression showed that infection (OR=5.291, P=0.048), MELD score (OR=1.105, P=0.017) and hepatic encephalopathy (OR=0.066, P=0.000) were independent factors affecting prognosis. Furthermore, the receiver operating characteristic curve of MELD score for predicting death showed that the cut-off value of MELD score was 26.50 (P=0.001).Conclusion By analyzing the data of 97 patients, many common clinical indicators are related to the prognosis of HRS. Controlling infection, improving liver and kidney function and preventing hepatic encephalopathy play the crucial roles in improving the prognosis of HRS.

Key words: Cirrhosis, Hepatorenal syndrome, Influencing factors, Prognosis