Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (2): 167-170.

• Liver Cancer • Previous Articles     Next Articles

A comparative study of radiofrequency ablation and microwave ablation combined with radiotherapy in the treatment of primary hepatocellular carcinoma with portal vein tumor thrombus

LIN Chuan1, WANG Qiu2, YOU Xin3   

  1. 1. Department of Oncology, the First People's Hospital of Yibin, Sichuan 644000, China;
    2. Department of Oncology, the Second People's Hospital of Yibin, West China Yibin Hospital, Sichuan University, Sichuan 644000, China;
    3. Department of Oncology, West China Hospital, Sichuan University, Chengdu, 610000, China
  • Received:2020-02-28 Online:2021-02-28 Published:2021-03-28

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Abstract: Objective To compare the effect of radiofrequency ablation and microwave ablation combined with radiotherapy on primary hepatocellular carcinoma with portal vein tumor thrombus.Methods One hundred patients who had primary hepatocellular carcinoma with portal vein tumor thrombus treated in Yibin secong people's hospital and West China Hospital from November 2016 to November 2017 were randomly divided into a radiofrequency ablation group and a microwave ablation group. The radiofrequency ablation group was treated with radiofrequency ablation combined with radiotherapy, while the microwave ablation group was treated with microwave ablation combined with radiotherapy. The ablation points and time of 2 groups were recorded. The levels of glutamyl transpeptidase (γ-GT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronidase (HA), laminin (LN), type Ⅲ procollagen (PC Ⅲ), fibrinogen (FIB) and T lymphocyte subsets, prothrombin time (PT) and activated partial thromboplastin time (APTT) were detected. The therapeutic effects and adverse reactions were compared. Results The ablation time of microwave ablation group was shorter than that of radiofrequency ablation group (P<0.05). After treatment, the levels of γ-GT, ALT, AST, HA, LN and PC Ⅲ in the microwave ablation group were lower than those in the radiofrequency ablation group, PT and APTT were shorter than those in the radiofrequency ablation group, and the level of FIB was higher than that in the radiofrequency ablation group (P<0.05). After treatment, the levels of CD3+ and CD4+ in the microwave ablation group were higher than those in the radiofrequency ablation group, and the level of CD8+ was lower than that in the radio frequency ablation group (P<0.05). The total effective rate of microwave ablation group was higher than that of radiofrequency ablation group (P<0.05). The complication rate of microwave ablation group was slightly lower than that of radiofrequency ablation group, but there was no significant difference between the 2 groups (P>0.05).Conclusion Microwave ablation combined with radiotherapy can improve the liver function, coagulation function, immune function and liver fibrosis in the patients with primary hepatocellular carcinoma and portal vein tumor thrombus.

Key words: Radiofrequency ablation, Microwave ablation, Primary hepatocellular carcinoma, Liver function