Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (2): 171-174.

• Liver Cancer • Previous Articles     Next Articles

The relation of peripheral blood levels of T lymphocyte subsets and NK cell to recurrence and metastasis in patients with primary liver cancer after operation

HE Qing1, LI Yang2, JIANG Li-hang1, DENG Pan-pan1, LIU Wei1, LIAO Yu-fei1   

  1. 1. Department of Clinical Laboratory, Wuxi District, No 904 Hospital of Chinese People's Liberation Army,Wuxi 214000, China;
    2. Department of Clinical Laboratory,Wuxi Traditional Chinese Medicine Hospital, Jiangsu 214000, China
  • Received:2020-04-03 Online:2021-02-28 Published:2021-03-28
  • Contact: LI Yang,Email:121400990@qq.com

PDF (PC)

282

Abstract: Objective To analyze the correlation of peripheral blood levels of T lymphocyte subsets and natural killer (NK) cell with recurrence and metastasis in primary liver cancer patients after operation.Methods The retrospective analysis was performed. Fifty-eight patients with primary liver cancer undergoing hepatectomy in our hospital from March 2017 to March 2019 were enrolled. All patients were divided into a recurrence and metastasis group (21 cases) and a non-recurrence and metastasis group (37 cases) according to postoperative follow-up. The peripheral blood of patients was collected, and the levels of T lymphocyte subsets and NK cell of the 2 groups were detected and compared. The regression analysis was performed to analyze the correlation of each index with recurrence and metastasis. Results The levels of CD3+, CD3+/CD4+, NK cell in recurrence and metastasis group were lower than those in non-recurrence and metastasis group, and the level of CD3+/CD8+ in recurrence and metastasis group was higher than that in non-recurrence and metastasis group (P<0.05). CD3+ level had no relation to postoperative recurrence and metastasis in patients with primary liver cancer. The levels of CD3+/CD4+, CD3+/CD8+ and NK cell may be the influencing factors for recurrence and metastasis (P<0.05).Conclusion Patients with primary liver cancer have immune dysfunction in different degrees. The immune dysfunction may be related to the postoperative recurrence and metastasis, which deserves clinical attention.

Key words: Primary liver cancer, Radical resection, Recurrence and metastasis, Peripheral blood T lymphocyte subsets, Natural killer cell, Correlation