Abstract: Objective To explore the medication situation and clinical characteristics of patients with drug-induced liver injury (DILI), to provide auxiliary judgment for clinicians. Methods The general information of 162 patients with DILI admitted in our hospital from 2018 to 2019 was collected, and clinical data including drugs previously used, clinical characteristics, laboratory data, and statistical analysis. Results Of the 162 patients with DILI, 60 were male (37%) and 102 were female (63%), with the majority in the 40-80 age group, accounting for 141(87%). Among the drugs that caused DILI, we found that Chinese patent medicines and Chinese medicine decoctions occupied the first place, among which Shouwu, Tripterygium wilfordii, Zongzi, Gukang capsules, and Xianling Guzhen capsules were the majority. Antitumor drugs and tuberculosis drugs were mostly used. Among 162 patients, fatigue was the most common in 117 cases (72.2%), followed by anorexia in 86 cases (53.1%) and urinary yellow in 67 cases (41.4%). Hepatocyte injury type was the most common type of DILI, and grade 1 liver injury was the most, accounting for 112 cases (69.1%). The differences in ALT, AST, ALP, and γ-GT levels among the three types of hepatocyte injury, cholestasis, and mixed types were statistically significant [318.50 (177.50-724.00)U/L vs 117.50 (67.00-231.50)U/L vs 321.00 (187.75-747.75)U/L, P=0.000; 223.50 (118.75-490.75)U/L vs 132.50 (69.00-206.75)U/L vs 224.00 (123.94-670.00)U/L, P=0.043; 190.00 (122.00-281.75)U/L vs 289.50 (263.00-507.00)U/L vs 347.00 (249.00-560.5)U/L, P=0.000; 164.50 (89.50-242.25)U/L vs 309.00 (143.50-506.00)U/L vs 283.00 (191.50-574.00)U/L, P=0.000]. In addition, the ALT, AST, APK, TB, and length of hospital stay of DILI patients caused by Chinese medicine were significantly higher than those of western medicine group [423.00 (238.00-728.50)U/L vs 190.00 (97.00-311.00)U/L, P=0.000; 345.00 (151.25-613.75)U/L vs 139.00 (82.65-223.00)U/L, P=0.000; 274.50 (207.75-355.25)U/L vs 220.00 (126.00-306.00)U/L, P=0.009; 66.5 (19.25-114.75)μmol/L vs 17.00 (11.00-33.00)μmol/L, P=0.000; 20 (15-24.75) vs 13.00 (9.00-17.00), P=0.000]. Conclusion DILI was more common in middle-aged and elderly women; and fatigue was the most obvious clinical manifestation of DILI patients. Whether it was herbal medicine or western medicine-mediated DILI, liver cell injury types were mostly; compared with western medicine, traditional Chinese medicine could cause liver damage more.

Key words: Drug-induced liver injury, Medication history, Clinical manifestations