Abstract: Objective Tto investigate the efficacy and safety of modified three-chamber and two-sac compression combined with somatostatin and lansoprazole in the treatment of portal hypertension esophageal and gastric varicose hemorrhage (EGVB).Methods In recent years, 55 patients with EGVB were divided into the observation group and the control group. The control group was treated with rehydration and expansion, somatostatin, proton pump inhibitor (PPI), etc. The observation group was treated with improved three-chamber and two-sac tube compression therapy based on the treatment. Results The success rate of hemostasis in the observation group at each time point of 1 h, 2 h, 4 h, 8 h and 12 h was higher than that of the control group, the bleeding control time, rebleeding rate, transfusion volume and hospitalization days were lower than that of the control group, and the improvement degree of portal venous pressure and child-pugh grading score was higher than that of the control group, with significant difference (P<0.05). No serious collateral damage was found in the observation group.Conclusion On the basis of conventional treatment, EGVB patients were treated with improved three-cavity and two-sac compression therapy, which significantly improved the hemostatic effect, improved the liver function, and reduced the complication rate. It is a simple, safe and effective clinical treatment.

Key words: Esophageal and gastric varicose bleeding, Sengstaken-Blakemore, Somatostatin, Lansoprazole, Hemostatic effect