Abstract: Objective To study the relationship between glycosylated hemoglobin (HbA1c) level and the effect of ultrasound-guided puncture in patients with diabetes mellitus (DM) and liver abscess (LA).Methods Fifty-six patients with DM and LA were treated in our hospital from January 2018 to December 2019. All patients were treated by percutaneous catheter drainage (PCD) under the guidance of ultrasound. The 56 patients were divided into good control group (HbA1c < 7%), general control group (7% < HbA1c ≤ 9%) and poor control group (HbA1c > 9%) according to the level of HbA1c. The clinical effect and complication rate of the 3 groups were compared. The Logistic regression analysis was used to analyze the influence factors of HbA1c. Results There were 20, 18 and 18 cases in good control group, general control group and poor control group, respectively. Fifty-five patients got the clinical recovery. There was a significant difference in clinical rehabilitation time among the 3 groups (P<0.05). The HbA1c was negatively correlated with clinical rehabilitation time (r=-0.519, P=0.000). The clinical effect in the good control group at 1 and 2 weeks after operation was better than that of the other 2 groups (P<0.05). The incidence rate of ascites, pleural effusion and acute renal failure in the good control group were significantly lower than those in the poor control group (P<0.05). The Logistic regression analysis showed that the renal insufficiency, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2 h PG), urinary microalbumin (mAlb) and blood uric acid (SUA) were the independent influence factors for HbA1c.Conclusion The level of HbA1c in patients with DM and LA is closely related to the effect of ultrasound-guided PCD. The HbA1c level can be affected by SUA, blood glucose and renal function, which should be paid more attention in clinical practice.

Key words: Diabetes mellitus, Liver abscess, Glycosylated hemoglobin, Percutaneous catheterization and drainage