Abstract: Objective To investigate the effect of N-acetylcysteine on liver and kidney function in patients with obstructive jaundice after percutaneous transhepatic cholangial drainage (PTCD).Methods A total of 110 patients with obstructive jaundice admitted to our hospital from May 2018 to March 2019 were selected as study objects. All patients were treated with PTCD to relieve biliary obstruction. According to the different treatment, they were randomly divided into the observation group and the control group, with 55 cases in each group. The control group was given conventional therapy after operation, and the observation group was given intravenous N-acetylcysteine treatment supplemented to conventional therapy. The indexes of liver function, biliary obstruction and kidney function were recorded in 2 groups 1 day before and 7 days after operation. Results There was no significant difference in the indexes of liver function (alanine aminotransferase, aspartate aminotransferase, γ-glutamine transpeptidase and alkaline phosphatase), biliary obstruction (total bilirubin, direct bilirubin and bile acid), and kidney function (urinary albumin, urinary retinol binding protein and urinary transferrin) between 2 groups 1 day before operation (P>0.05). Liver function, biliary obstruction and kidney function improved 7 days after PTCD in 2 groups (P<0.05). And all these indexes improved more in observation group than control group (P<0.05).Conclusion N-acetylcysteine can protect liver and kidney function of patients with obstructive jaundice after PTCD, with high clinical value.

Key words: N-acetylcysteine, Obstructive jaundice, Percutaneous transhepatic cholangial drainage, Liver function, Kidney function