Abstract: Objective To investigate the efficacy of bicyclol in the treatment of transaminase and lipid in patients with nonalcoholic fatty liver disease (NAFLD), and to search for related literature for meta analysis.Methods From PubMed, MEDLINE, EMBASE English database, Wanfang database, VIP Chinese network and HowNet Chinese database, the relevant literatures of bicyclol and NAFLD were searched. After literature screening and data extraction, the time limit was set as from the establishment of the database to December 2019. Cochrane bias risk table was used to evaluate the quality of literature, and Revman 5.3 software was used for statistical analysis. Results In this study, 8 articles were included, and 873 patients were enrolled, 446 in the experimental group and 427 in the control group. After 2-6 months of bicyclol treatment, serum ALT of NAFLD patients decreased significantly[WMD=-13.19, 95％CI:-22.0～-4.37, P=0.003];After 2-6 months of treatment, the serum TG of NAFLD patients decreased significantly[WMD=-0.38, 95％CI:-0.74～-0.02, P=0.04];After 2-6 months of treatment, the serum TC of NAFLD patients decreased significantly [WMD=-0.21, 95％CI:-0.37～-0.06, P=0.007].Conclusion Bicyclol can effectively reduce the levels of ALT, TG and TC in serum of patients with non-alcoholic fatty liver disease.

Key words: Bicyclol, Nonalcoholic fatty liver disease, Efficacy, Meta analysis