Abstract: Objective To investigate the influence of different degrees of cirrhosis on the prognosis of the patients with hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC).Methods One hundred and eight patients with HBV-HCC from January 2016 to October 2020 were enrolled as the research subjects. The survival rate was calculated. The levels of clinicopathological characteristics of patients with different degrees of cirrhosis were compared. The relationship between the degree of cirrhosis and prognosis was analyzed.Results During 2- to 56-month follow-up, 26 of the 108 patients died. The survival rate was 75.93%. The prognosis of patients with different degrees of liver cirrhosis was significantly different (P<0.05). There were significant differences in tumor differentiation, vascular invasion and tumor staging among patients with different degrees of cirrhosis (P<0.05). The Cox multivariate regression model showed that the differentiation degree [95% confidence interval (CI) = 1.859~4.887, hazard ratio (HR) = 3.014, P<0.001], vascular invasion (95%CI=1.075~7.403, HR=2.821, P=0.035), tumor stage (95%CI=1.602~3.867, HR=2.489, P<0.001), treatment plan (95%CI=1.462~2.971, HR=2.084, P<0.001) and the degree of cirrhosis (95%CI=1.118~1.580, HR=1.329, P=0.001) were independent factors for the prognosis of HBV-HCC. According to Cox analysis, the prediction model was as follows: Y₂=1.103×X₁+1.037×X₂+0.912×X₃+0.734×X₄+0.284×X₅ (X₁=degree of differentiation, X₂ = vascular invasion, X₃ = tumor stage, X₄ = treatment, X₅ = degree of cirrhosis). Area under the curve (AUC) of the model to predict the prognosis was 0.840 (sensitivity = 0.042, 95%CI = 0.758-0.922, P<0.001).Conclusion The degree of liver cirrhosis in patients with HBV-HCC is closely related to the prognosis, and the prediction model based on the degree of liver cirrhosis has a high accuracy in predicting the prognosis.

Key words: Hepatitis B virus, Liver cancer, Liver cirrhosis, Prognosis