The relationship between sustained virological response and re-bleeding risk of chronic hepatitis C patients after endoscopic management of gastroesophageal varices

Abstract

Abstract: Objective To investigate the impact of sustained virological response (SVR) on the re-bleeding risk of chronic hepatitis C patients after endoscopic management of gastroesophageal varices bleeding (GVB).Methods A total of 49 patients admitted to Zhongshan Hospital, Fudan University with HCV related GVB were included in this study. They were divided into SVR group (N=26 patients) and non-SVR group (N=23 patients) according to their serum HCV RNA levels detected at the time of primary endoscopic therapy for GVB by esophageal variceal ligation (EVL) combined with histoacryl injection (HI). The occurances of re-bleeding and other complications of cirrhosis, and the survival rates of these patients in three years after endoscopic treatment were follow-up.Results Kaplan-Meier survival analysis showed that there were no significant differences in the cumulative rebleeding-free rates at 1-year, 2-year and 3-year between the SVR group and the non-SVR group, the same went for the cumulative survival rates between these two groups. The results of Multivariate analysis showed that the clearance of HCV did not influence the efficacy of endoscopic management of HCV-related GVB. The endoscopic treatment of EVL plus HI is an independent protective factor against re-bleeding in HCV-related cirrhotic patients with GVB.Conclusion The clearance of HCV RNA did not influence the efficacy of endoscopic management of HCV-related GVB. EVL plus HI can be the optimal treatment selection in these patients.

Key words: Hepatitis C related cirrhosis, Sustained virological response, Gastroesophageal varices bleeding, Endoscopic treatment, Re-bleeding

HUANG Xiao-quan, WU Ling, JIANG Si-yu, LI Feng, CHEN Shi-yao. The relationship between sustained virological response and re-bleeding risk of chronic hepatitis C patients after endoscopic management of gastroesophageal varices[J]. Chinese Hepatolgy, 2021, 26(6): 597-601.

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