Sarcopenia may predict the occurrence of hepatic encephalopathy in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt

Abstract

Abstract: Objective To investigate the predictive value of sarcopenia on the occurrence of hepatic encephalopathy (HE) in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt (TIPSS).Methods A retrospective analysis of 301 patients who underwent TIPSS therapy from January 2015 to August 2019 were enrolled in these study. The skeletal muscle areas of the patients at the L3 level were measured by CT images and were analyzed by software to define sarcopenia. Risk factors for HE were analyzed by binary logistic regression.Results Among patients with liver cirrhosis who underwent TIPPS, the incidence of sarcopenia was 63.8%. Age (OR:1.088, 95%CI:1.024-1.156), MELD score (OR:1.004, 95%CI:1.003-1.005), HE history (OR:1.922, 95%CI: 1.487-2.357) and sarcopenia (OR: 2.745, 95%CI: 2.311-2.902) were independent risk factors for postoperative HE.Conclusion The incidence of sarcopenia in cirrhotic patients underwent TIPSS is relatively high. Sarcopenia may predict the occurrence of HE in liver cirrhotic patients after TIPSS surgery. Caution should be taken on such patients.

Key words: Sarcopenia, Liver cirrhosis, Transjugular intrahepatic portosystemic shunt, Hepatic encephalopathy

YU Rui, SUN Qian, SHI Qiang-wei, WANG Chun-feng, YAO Jian-ning, ZHANG Lian-feng. Sarcopenia may predict the occurrence of hepatic encephalopathy in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt[J]. Chinese Hepatolgy, 2021, 26(6): 602-605.

References

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