Abstract: Objective To investigate the association of baseline serum vitamin D level with the 24-week virological response of tenofovir treatment on chronic hepatitis B patients.Methods A total of 115 patients who were hospitalized in the department of liver diseases of the third people’s hospital of Shenzhen from November 2017 to November 2019, and met the inclusion criteria were enrolled in this study. Baseline clinical data were collected including demographic information, virological indicators, blood routines, Liver function, blood coagulation function and serum vitamin D level. According to the quantitative results of hepatitis B viral load at 24 weeks of treatment, the patients were divided into positive and negative groups. The relationship between vitamin D level and virological response was analyzed by logistic multivariate analysis. Gender, HBeAg status and HBV DNA level were used as the stratified factors.Results The baseline serum 25(OH)D level of the positive group was significantly lower than that of the negative group (P=0.002). Multivariate analysis showed that the 24-week HBV DNA negative conversion rate gradually increased with an increase of baseline 25 (OH)D level. In the subgroup analysis, the 24-week HBV DNA negative conversion rate all increased with the increase of baseline 25 (OH)D level.Conclusion The level of 25(OH)D is an independent factor associated with the 24-week virological response of tenofovir treatment on chronic hepatitis B patients.

Key words: 25(OH)D level, Tenofovir disoproxil fumarate, Virological response, Chronic hepatitis B