Abstract: Objective To explore the value of liver stiffness-spleen diameter-to-platelet ratio score (LSPS) in evaluating the short-term prognosis of patients with alcoholic cirrhosis complicated with esophageal gastric variceal bleeding (EGVB).Methods A total of 90 patients with alcoholic cirrhosis and EGVB who were hospitalized in Second Central Hospital of Baoding from May 2017 to May 2018 were retrospectively analyzed. According to whether the patients suffered from rebleeding within 4 weeks, they were divided into bleeding group (25 cases) and non-bleeding group (65 cases). The general clinical data, blood routine, liver and kidney functions, coagulation function indexes were observed and compared. The liver hardness, portal vein and spleen diameter of the two groups were measured and LSPS were calculated. The difference between these two groups was analyzed by single factor analysis, followed by Logistic regression analysis to identify the risk factors of rebleeding. In addition, the predictive value of LSPS score for short-term rebleeding in patients with alcoholic cirrhosis complicated with EGVB was evaluated by receiver operating characteristic curve (ROC).Results The bleeding volume, the diameter of portal vein, the diameter of spleen, the hardness of liver, the proportion of liver function Child-Pugh grade C, and LSPS in the bleeding group were significantly higher than those in the non-bleeding group (P<0.05). Logistic regression analysis showed that the increases of the diameter of portal vein, the diameter of spleen, the hardness of liver and LSPS were the risk factors for the recurrence of bleeding in a short period of time. In addition, ROC curve showed that the predictive value of LSPS (AUC=0.960) for short-term rebleeding was significantly higher than those of portal vein diameter (AUC=0.822), spleen diameter (AUC=0.866) and liver hardness value (AUC=0.860), the cutoff value was 4.447, and the corresponding sensitivity and specificity were 88.00% and 92.30%, respectively.Conclusion The diameter of portal vein, the diameter of spleen, the hardness of liver and LSPS can affect the short-term prognosis of patients, and LSPS has a higher predictive value for the short-term rebleeding in patients with alcoholic cirrhosis and EGVB.

Key words: Liver stiffness-spleen diameter-to-platelet ratio score, Alcoholic cirrhosis complicated with esophageal gastric variceal bleeding, Short-term prognosis