Abstract: Objective To analyze the clinical manifestations, laboratory tests and other clinical features of acute drug-induced liver and kidney injuries.Methods The clinical data of patients with acute DILI and AKI admitted to the Fifth Medical Center of PLA General Hospital from January 1, 2011 to December 31, 2019 were retrospectively analyzed, and the clinical characteristics were discussed.Results Among the 15 patients, 9 were female, 8 were ≥60 years old, with an average age of 64.88±10.30 years old. The most common clinical manifestations were anorexia (10 cases), followed by fatigue (9 cases) and yellow urine (8 cases). The main clinical classification is hepatocyte type (46.67%). The degree of liver damage was all grade 3 and above, and the main type of kidney damage was stage 1 (60%). Ascites was the most common complication.Conclusion Acute DILI with AKI is mainly seen in the elderly. The clinical classification of acute DILI with AKI is mainly hepatocyte type,and the degree of liver damage is severe. The appearance of complications affects the patients’ prognosis.

Key words: Drug induced liver and kidney Injuries, Disease attributes