Abstract: Objective To compare and analyze the influence of informationized follow-up and intervention on the medication compliances of patients with chronic hepatitis B (CHB).Methods A total of 264 eligible patients were included From October 2014 to October 2017 who were diagnosed as CHB and hepatitis B related cirrhosis in outpatient and inpatient departments of Huizhou Sixth People's Hospital were collected, of which 42 were diagnosed as cirrhosis. The patients were divided into three groups by stratified random sampling method, with 87 cases in WeChat+telephone follow-up group (group A), 88 cases in telephone follow-up group (group B) and 89 cases in control group (group C). All patients were followed-up for 2 years and compared for liver functions, the number of patients with liver cirrhosis, and the time of discontinuing anti-viral treatment of enticavir between the groups.Results After follow-up for two years, there was a significant difference in the numbers of lost visitors among these three groups. The levels of ALT (Z=-3.218, P=0.02), AST(Z=-2.749, P=0.03), Alb(Z=1.746, P=0.04), hepatitis B virus DNA (ALB) were statistically different between group A and group B. The levels of ALT(Z=-11.089, P<0.001), AST(Z=-9.247, P=0.01), TBil(Z=-7.623, P=0.01), APRI (Z=-4.81,P=0.02), hepatitis B viral DNA (Z=-10.078, P< 0.001) between group A and group C were significantly different, but there was no difference in FIB-4 index. The comparison between group B and group C showed that ALT(Z=-1.275, P=0.04), AST(Z=-2.045,P=0.03), TBil(Z=-3.762, P=0.02), APRI (Z=-1.466,,P=0.04) were statistically different. After 2-years’ follow-up, there were 12 cirrhotic patients in group A, 16 cirrhotic patients in group B and 24 cirrhotic patients in group C. There is no significant difference between group A and B (χ²=0.945, P=0.408), and group B and C (χ²=2.741, P=0.103), but there is significant difference between group A and group C (χ²=6.843, P=0.013). Within two years, 15 patients in group A, 28 patients in group B and 61 patients in group C stopped using entecavir. There were significant differences among these three groups (χ²=25.061, P< 0.001).The results of Kaplan-meier analysis showed that entecavir use in group A patients was longer than that in group B (83.0% vs 68.5) P=0.016) and group C (83.0% vs 33.7%, χ²=61.601, P< 0.001), while group B patients took enticavir longer than that of group C (63.5% vs 33.7%, χ²=32.451, P< 0.001).Conclusion Informationized intervention may increase the compliance of CHB patients to antiviral treatment and therefore reduce the incidence of liver function abnormalities and liver cirrhosis.

Key words: Informatization intervention, Patients with HBV infection, Compliance