Abstract: Objective To analyze the influencing factors of infection after interventional treatment of primary liver cancer patients with diabetes mellitus, so as to establish a prevention and treatment plan for the post-operative infection in the future.Methods The clinical data of 42 patients with primary liver cancer complicated with diabetes mellitus who were infected after interventional therapy from February 2019 to October 2020 were retrospectively analyzed and enrolled into the infection group; the clinical data of 40 patients with diabetes mellitus and primary liver cancer who did not get infection after interventional surgery at the same period of time were collected and enrolled into the non-infection group. Single and multi-variant analyses were performed on the baseline data of these two groups of patients to find out the influencing factors of infection post interventional therapy.Results The binary variables including duration of diabetes, duration of primary liver cancer, radiotherapy and chemotherapy, Child-Pugh classification, perioperative invasive operation, anemia and index of insulin resistance obtained by single variant analysis were taken as independent variables, and the incidence of infection in patients with diabetes mellitus complicated with primary liver cancer after interventional therapy was taken as a dependent variable (1=occurred, 2=not occurred). It was shown that the course of diabetes mellitus, the course of primary liver cancer, radiotherapy and chemotherapy, Child-Pugh classification, perioperative invasive operation, anemia, insulin resistance were the influencing factors of post-operative infection after interventional therapy in primary liver cancer patients with diabetes mellitus(OR=73.667, 85.500,61.667,380.00,74.000,218.667,68.889,P<0.05[gh1]).Conclusion The course of diabetes (≥1 year), the course of primary liver cancer (≥1 year), radiotherapy and chemotherapy (yes), child Pugh classification, perioperative invasive operation (≥ 3 times), anemia (yes), and the existence of insulin resistance were the influencing factors of infection after interventional surgery in primary liver cancer patients with diabetes mellitus. It is important to take protective strategies in these patients for improving their outcome after interventional therapy.

Key words: diabetes mellitus, primary liver cancer, interventional therapy, infection, influencing factors