Hepatotoxic pyrrolizidine alkaloid detection accurately diagnosed HPA-HSOS

Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (10): 1112-1115.

• Drug-Induced Liver Injury • Previous Articles Next Articles

Hepatotoxic pyrrolizidine alkaloid detection accurately diagnosed HPA-HSOS

SHAO You-lin¹, XIONG Ai-zhen², ZHANG Suo-cai¹, WU Jian-ming¹, MA Chun-ming¹, GUO Feng-cai¹, LIU Long-gen¹

1. Department of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, China;
2. The Ministry of Education Key Laboratory for Standardization of Chinese Medicines and the State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China

Received:2022-05-27 Online:2022-10-31 Published:2022-11-22
Contact: LIU Long-gen, Email:ssewllg@163.com; XIONG Ai-zhen, Email:a.z.xiong@hotmail.com

Abstract

Abstract: Objective To investigate the feasibility of detecting hepatotoxic pyrrolizidine alkaloids (HPA) in patients’ ingestion in the diagnosis of HPA-hepatic sinusoidal obstruction syndrome (HSOS). Methods Clinical datas were collected from 1 patient taking Gynura Segetum Lour and 4 patients taking “Sanqi powder” or “Sanqi wine”. Acquity Ultra Performance LCTM-Micromass ZQ 2000(UPLC-MS) was used to determine the levels of six major hepatotoxic pyrrolizidine alkaloids, including seneciphylline, seneciphylline N-oxide, senecionine, senecionine N-oxide, seneciphyllinine and seneciphyllinine N-oxide. Results ① 4 patients were diagnosed with HPA-HSOS, and 1 patient was excluded from HPA-HSOS. ② HPA was found in roots, stems and leaves of Gynura Segetum, and the content of HPA was root > leaf > stem. Conclusion HPA-HSOS can be accurately diagnosed by detecting HPA in patients’ ingestion.

Key words: Gynura segetum, Hepatic sinusoidal obstruction syndrome, Hepatotoxic pyrrolizidine alkaloid, Accurate diagnosis

SHAO You-lin, XIONG Ai-zhen, ZHANG Suo-cai, WU Jian-ming, MA Chun-ming, GUO Feng-cai, LIU Long-gen. Hepatotoxic pyrrolizidine alkaloid detection accurately diagnosed HPA-HSOS[J]. Chinese Hepatolgy, 2022, 27(10): 1112-1115.

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Hepatotoxic pyrrolizidine alkaloid detection accurately diagnosed HPA-HSOS

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