Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (10): 1116-1119.

• Drug-Induced Liver Injury • Previous Articles     Next Articles

Diagnostic value of serum M30 and M65 for liver inflammation in patients with drug-induced liver injury

KAN Yan-ting, WU Wei-feng, YANG Yong-feng   

  1. Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing Second Hospital, Jiangsu 210003, China
  • Received:2021-12-01 Online:2022-10-31 Published:2022-11-22
  • Contact: YANG Yong-feng, Email:yangyongfeng@njucm.edu.cn

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Abstract: Objective To determine the diagnostic value of serum M30 and M65 for liver inflammation in patients with drug-induced liver injury (DILI). Methods From June 2020 to June 2021, 37 patients with drug-induced liver injury were selected from the First Department of Hepatology, Nanjing Second Hospital. According to the degree of liver inflammation at admission, they were divided into mild-moderate group (24 cases) and severe group (15 cases), and 18 healthy people were selected as control group. Enzyme-linked immunosorbent assay was used to detect the difference of serum M30 and M65 levels between DILI patients and healthy controls, and the changes of serum M30 and M65 levels before and after treatment. Analyzing the correlation between serum M30 and M65 levels and liver function indexes, including alaninetransaminase (ALT), aspartatetransaminase (AST), gamma-glutamyl transferase (γ-GT), alkaline phosphatase (ALP). Results Serum M30 in mild-moderate group and severe group were (256.41 ± 50.61) U/L and (1116.69 ± 136.83) U/L respectively, and serum M65 in mild-moderate group and severe group were (1007.98 ± 291.15) U/L and (3963.68 ± 614.62) U/L respectively, both were higher than healthy control group (P<0.05). After treatment, there was no significant difference between M30 detected after liver inflammation recovery and healthy control group (P>0.05), but M65 was still higher than that of healthy control group (P<0.05). M65 was positively correlated with ALT (r=0.523, P<0.05), AST (r=0.512, P<0.05), γ-GT (r=0.434, P<0.05) and ALP (r=0.423, P<0.05). M30 was positively correlated with ALT (r=0.748, P<0.05) and AST (r=0.525, P<0.05). There is a positive correlation with γ-GT (r=0.325, P>0.05) and ALP (r=0.415, P>0.05), but there is no statistical difference. Conclusion Serum M30 and M65 levels are sensitive indicators to reflect hepatocyte necrosis and apoptosis in patients with DILI, which are related to liver inflammation and have certain clinical auxiliary value.

Key words: Drug-induced liver injury, M30, M65