Abstract: Objective To analyze how to establish a collaborative research platform of prevention and treatment for autoimmune liver disease (AILD) to manage AILD, reduce the risk of canceration in patients with AILD, improve the quality of life and prolong the life of patients. Methods The characteristics and advantages of the collaborative research platform of prevention and treatment for AILD, the electronic health records of AILD patients, the implementation and management of the platform team, the deficiencies and the improvement measures of the collaborative research platform were analyzed. The collaborative research platform of prevention and treatment of AILD focused on personnel training, forming an efficient, mutual assistance and comprehensive team, emphasizing the implementation of a collaborative research model centered on patients, AILD diagnosis and treatment. Results Since the implementation and management of the collaborative research platform of prevention and treatment for AILD, our department had treated 136 patients with liver disease in Changde for more than 2 years, including 49 patients diagnosed with AILD or overlap syndrome. Patients had already been in the middle and late disease stage admitted into our department. Patients had achieved clinical and biochemical index remission and prevented further progression to cirrhosis or liver failure after diagnosis and treatment from the collaborative research platform of prevention and treatment for AILD. The collaborative research platform combining AILD prevention and treatment holded more than 100 special lectures qriented by AILD and other liver diseases every year, distributed more than 2,000 health handbooks, hosted large-scale free clinic activities on World Hepatitis Day, helped AILD patients to register on the collaborative research platform and check the test results based on network, communicated with doctors to get illness information, save time and cost of unnecessary round-trip hospital consultation. In addition, patients could also actively participate in health lectures and communicate with doctor by telephone, which significantly improved the health management ability and the compliance of therapy of AILD patients. Conclusion The collaborative research platform of prevention and treatment of AILD provides patients best diagnosis and treatment based on the “many-to-one” service mode, which helps to improve the prognosis of AILD, improve the quality of life and reduce disease burden.

Key words: Autoimmune liver disease, Collaborative research platform, Management, Follow-up