Predictive value of 3 scoring systems on liver injury in patients with primary hepatocellular carcinoma after hepatectomy

Abstract

Abstract: Objective To investigate the predictive value of 3 scoring systems on liver function in patients with hepatocellular carcinoma (HCC) after hepatectomy.Methods A total of 62 patients with HCC treated by hepatectomy in our hospital from October 2020 to March 2021 were enrolled. The clinical data of all the cases were collected. The predictive value of 3 scoring systems on liver function of patients after operation.Results A total of 62 patients were involved in the study. All the patients were Child-Pugh A, the median ICG R15 was 4.5(3.5, 6.8)%. Twenty-six patients were in ALBI grade 1, and 36 patients were in ALBI grade 2. Among 62 patients, 15 (24.19%) were developed posthepatectomy liver failure (PHLF). Multivariate analysis showed that ICG R15 greater than 10% (OR=9.111, 95%CI 1.910-43.465, P=0.006) was a risk factor for PHLF. Compared to the patients with ICG R15 less than 10% ,patients with ICG R15 greater than 10% had higher total bilirubin (TBIL) and international normalized ratio (INR) at day 1, day 3 and especially day 7 (TBIL: 29.7 μmol/L vs 16μmol/L, P=0.042, INR: 1.29 VS 1.20, P=0.032) after operation.Conclusion ICG R15 greater than 10% is a risk factor for PHLF in HCC patients with Child-Pugh A after hepatectomy. ICG R15 scoreing system can stably reflect the dynamic changes of postoperative liver function.

Key words: Primary hepatocellular carcinoma, Liver function reserve, Hepatic insufficiency, Indocyanine green

ZHANG Xiao-feng, ZHANG Da-li, NIU Xiao-feng, HE xi, FENG Dan-ni, LIU Zhen-wen, WANG Hong-bo. Predictive value of 3 scoring systems on liver injury in patients with primary hepatocellular carcinoma after hepatectomy[J]. Chinese Hepatolgy, 2022, 27(11): 1167-1169.

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