Nutritional risk is associated with an increase of postoperative infection after endoscopic treatment for esophagogastric variceal bleeding in liver cirrhosis

Abstract

Abstract: Objective To investigate the incidence rate of the nutritional risk on cirrhosis patients with esophagogastric variceal bleeding (EGVB). To investigate the correlation between nutritional risk and postoperative infection after endoscopic therapy.Methods A total of 163 patients with EGVB who received endoscopic therapy were involved. The nutritional risk was evaluated based the Nutrition Risk Screening Sore (NRS2002). The data including medical history, liver function, blood ammonia levels, Child-Pugh scores, B ultrasound and postoperative infection status were colledcted.Results According to the NRS2002 scores, there were 79 (48.5%) patients with nutritional risk. The level of serum albumin (27.87 ± 3.70) g/L and prealbumin values (0.08 ± 0.02)g/L of patients with nutritional risk were significantly lower (P<0.05) than that without the nutritional risk (35.76 ± 4.32, 0.11 ± 0.03) g/L. The blood ammonia, prothrombin time (PT), international normalized ratio (INR) and Child-Pugh B/C, ascites and postoperative infection proportion were significantly increased in patients with nutritional risk (P<0.05). The incidence of postoperative infection after endoscopic treatment was 19.0% in all patients, 32.9% in patients with nutritional risk, and 6.0% in patients without nutritional risk. Age ≥ 60 (OR:4.610; 95%CI:1.028-20.673; P=0.046), WBC level (OR:1.324; 95%CI:1.036-1.693; P=0.025) and NRS2002 ≥ 3(OR: 11.670; 95%CI: 1.832-74.334; P=0.009) were significant risk factors.Conclusion The patients with nutritional risk are more likely to suffer from postoperative infection after endoscopic treatment. It is neccessary for cirrhosis patients with EGVB to receive nutritional assessment as well as clinical interventions before and after the endoscopic treatment.

Key words: Esophagogastric variceal bleeding, Endoscopic treatment, Nutritional risk, Postoperative infection, Risk factors

LOU Jian-jun, ZHANG Fang-fang, HUANG Yan, SANG Yuer. Nutritional risk is associated with an increase of postoperative infection after endoscopic treatment for esophagogastric variceal bleeding in liver cirrhosis[J]. Chinese Hepatolgy, 2022, 27(11): 1183-1188.

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