Abstract: Objective To further clarify the prognostic factors of intrahepatic cholangiocarcinoma. Methods The data of 186 patients with intrahepatic cholangiocarcinoma who were admitted from January 2015 to January 2020 were retrospectively collected. The survival status of all patients was followed up by telephone. Multivariate analysis was used to analyze the influencing factors of overall survival. Kaplan-Mier analysis was used to describe the overall survival and disease progression free period. Cox regression model was used to analyze the prognostic factors. Results The 1-, 3-, and 5-year survival rates were 80.6%, 32.2%, and 17.4%, respectively; the 1-, 3-, and 5-year progression free survival rates were 57.6%, 22.9%, and 13.0%, respectively. Multivariate analysis showed that TNM stage IV (HR: 2.77; 95%CI: 1.43-5.36; P=0.002), radical surgery (HR: 0.47; 95%CI: 0.26-0.84; P=0.012), lymph node metastasis (HR: 2.11; 95%CI: 1.33-3.35; P=0.001), vascular invasion (HR: 1.74; 95%CI: 1.04-2.89; P=0.033) were independent factors affecting overall survival. Conclusion TNM stage IV, radical operation, lymph node metastasis and vascular invasion are independent factors affecting the overall survival of patients with intrahepatic cholangiocarcinoma.

Key words: Intrahepatic cholangiocarcinoma, Prognosis, Factors